Dual Secured Therapeutic Peptide Delivery System for Cancer Therapy


Reference #:  00925

The University of South Carolina is offering licensing opportunities for a therapeutic peptide delivery system for cancer treatment that can specifically target tumor tissue while being non-toxic to red blood cells. 



The National Institutes of Health estimated that the annual costs of cancer top $226 billion.  Researchers are dedicated to finding better treatments and have extensively explored therapeutic peptides (e.g. melittin) because they have wide-spectrum lytic properties and are less likely to develop resistance. However, their in vivo application is compromised by serious off-target toxicity. 


Invention Description:

The invention is a therapeutic peptide delivery system, dual secured nano-bee (DSNB), which is able to target to tumor tissue specifically while sparing red blood cells during circulation. This DSNB system is effective on a wide-spectrum of cancers, including MCF-7 breast cancer, NCI/ADR-Res and SKOV-3 ovarian cancer cells, and HCT-116 colon cancer cell. For most of the tested cancer cell lines, DSNB killed 100% cells at the melittin concentration of 5 μM. Most importantly, DSNB showed no toxicity to red blood cells at the same concentration. This polymer-based nanoparticle system can also be applied for the delivery of other therapeutic peptides and proteins.

Potential Applications:

The peptide delivery system can be used in the treatment of a number of cancers and can also be applied for the delivery of other therapeutic peptides and proteins.

Advantages and Benefits:

  • Delivers therapeutic peptides specifically to tumor tissue while showing no toxicity to red blood cells during circulation
  • Is effective against a wide spectrum of cancers
  • Can also be used to deliver other therapeutic peptides and proteins
Patent Information:
Title App Type Country Serial No. Patent No. File Date Issued Date Expire Date Patent Status
Dual secured therapeutic peptide delivery system for cancer therapy Utility United States 13/610,109 8,809,277 9/11/2012 8/19/2014 9/11/2032  
For Information, Contact:
Technology Commercialization
University of South Carolina
Peisheng Xu
Bindu Thapa
Bei Cheng
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