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Abbapolins as Inhibitors and Degraders of Polo-Like Kinases
Reference #: 01593 The University of South Carolina is offering licensing opportunities for Abbapolins as Inhibitors and Degraders of Polo-Like Kinases Background: There are no effective treatments for castration-resistant prostate cancers as all current therapies eventually fail. Invention Description: Novel chemicals called abbapolins are described...
Published: 4/2/2024
|
Inventor(s):
Campbell Mcinnes
,
Michael Wyatt
,
Danda Chapagai
,
Jessy Stafford
,
Gursanker Ramamoorthy
Keywords(s):
abbapolin
,
drug discovery
,
peptide
,
Polo Like Kinase
Category(s):
Biomedical and Life Sciences
,
Health Sciences
Macrocyclic Dimerization Inhibitors of Raf Kinases
Reference #: 01338The University of South Carolina is offering licensing opportunities for Macrocyclic Dimerization Inhibitors of Raf Kinases.Background:Despite the clinical success of B-Raf inhibitors like vemurafenib in treating metastatic melanoma, resistance has emerged through “paradoxical MEK/ERK signaling” where rather than blocking...
Published: 8/2/2024
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Inventor(s):
Campbell Mcinnes
Keywords(s):
Category(s):
Chemistry and Biochemistry
,
Biomedical and Life Sciences
,
Health Sciences
Selective Inhibition of the Polo-Like Kinase 1 PBD for Cancer Therapy
Reference #1307: Selective Inhibition of the Polo-Like Kinase 1 PBD for Cancer TherapyThe University of South Carolina is offering licensing opportunities for the Selective Inhibition of the Polo-Like Kinase 1 PBD for Cancer Therapy.Background:Polo-like kinase 1 (PLK1) has been shown to be over-expressed in a number of tumors. Its expression has been...
Published: 9/4/2022
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Inventor(s):
Campbell Mcinnes
Keywords(s):
Category(s):
Chemistry and Biochemistry
,
Biomedical and Life Sciences
,
Health Sciences
Structural Analysis of the CDK4/cyclin D1 Substrate Recognition Site and Basis for p27 and Inhibitor Binding
Reference #: 00829 Invention Description: An alternative strategy for inhibition of the cyclin dependent kinases in anti-tumor drug discovery is afforded through the substrate recruitment site on the cyclin positive regulatory subunit. This approach offers the potential for generating cell cycle-specific CDK inhibitors and to reduce the inhibition...
Published: 9/2/2022
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Inventor(s):
Campbell Mcinnes
,
Shu Liu
Keywords(s):
Category(s):
Biomedical and Life Sciences
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