Regenerative Tissue-Mimetic Multilayer Fused Microgel-Cell Construct

Description:

Reference #: 01470

The University of South Carolina is offering licensing opportunities for Regenerative Tissue-Mimetic Multilayer Fused Microgel-Cell Construct

Background:

Tissue engineering aims to make cellular constructs for implantation in an injured tissue defect in a human patient to restore, maintain, repair, regenerate or improve the function of the injured tissue.

Invention Description:

A novel composition and process to form multilayer microgel-cell construct as constructs for implantation in a tissue defect using decellularized, micronized tissue particles as microcarriers for cell expansion as well as a scaffold for delivery to the site of injury.

Potential Applications: 

Natural tissue-specific microcarriers for culture and expansion of human cells: Currently, human cells are commercially expanded on tissue culture bioreactors with synthetic microcarriers like polystyrene, dextran, or gelatin microbeads. These microcarrier-based cell substrates are synthetic and general in nature, meaning that the substrate does not mimic that of the natural tissue. As these microcarriers are not natural to the expanded cells, a three-step process is using the cells for tissue regeneration.

Advantages and Benefits:

Currently, human cells are commercially expanded on cell culture bioreactors with synthetic microcarriers that do not mimic that of the natural tissue. As these microcarriers are not natural to the expanded cells, the cells are detached and separated from the microcarriers, reseeded in a porous scaffold, and cultured in a bioreactor prior to implantation. The detachment of the cells from microcarriers and reseeding the cells in a scaffold negatively affects cell viability and functionality. There is a need to simplify the aforementioned process of cell expansion, separation, scaffold reseeding, and cultivation in bioreactors in order to increase cell viability and functionality, reduce contamination and cost, and enhance quality of the tissue regeneration implant.

Patent Information:
Title App Type Country Serial No. Patent No. File Date Issued Date Expire Date Patent Status
Regenerative Tissue-Mimetic Multilayer Fused Microgel-Cell Construct Utility United States 17/691,262   3/10/2022     Filed
For Information, Contact:
Omar Iyile
Technology Associate
University of South Carolina
oiyile@email.sc.edu
Inventors:
Esmaiel Jabbari
Keywords:
Articular cartilage injury
articular cartilage microcarriers
articular cartilage mimetic cellular construct
articular cartilage regeneration
articular cartilage zonal-mimetic scaffold
cellular construct
cellular tissue construct
decellularized articular cartilage microcarrier
mesenchymal stem cells
microgels for cell expansion
multilayer cellular construct
regeneration of zonal structure of articular cartilage
stem cell expansion
tissue scaffold
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