Removal of Bacterial Endotoxins


Reference #: 00803


Bacterial endotoxins are residues from gram negative bacteria that can cause serious health problems if introduced into the blood stream. Therefore, bacterial endotoxins are a serious concern for companies in the reusable medical device field.

Invention Description:

The invention consists of a cleaning method for the complete removal of endotoxins from biomaterials and metallic substrates.

Potential Applications:

  • Hospitals, 
  • Clinics, 
  • Out-patient surgery centers, and 
  • Any company that requires endotoxin removal from reusable medical devices 
  • Small clinical settings will also be aided by this cleaning method because of the non-toxic fluid employed. 

Advantages and Benefits:

Endotoxins are completely removed without harming the substrate device. This technique is especially attractive because it employs non-hazardous, non-toxic, non-corrosive fluids and is suitable for heat-sensitive biomaterials. The cleaning method is also able to rapidly penetrate and remove contaminants from complex structures and devices.

Patent Information:
Title App Type Country Serial No. Patent No. File Date Issued Date Expire Date Patent Status
Removal of Bacterial Endotoxins Utility United States 13/197,261 9,296,981 8/3/2011 3/29/2016   Issued
For Information, Contact:
Technology Commercialization
University of South Carolina
Michael Matthews
Pedro Tarafa
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