Artificial Myocardium

Reference #:  00166

Invention Description:

This invention is a 3-dimensional, multilayered, functional, artificial myocardium. The subject invention is composed of appropriate extracellular matrix (ECM), nutritional requirements, a critical ratio of myocytes and fibroblasts, all in an in vitro environment.

Potential Applications:

·       Implantation to repair or patch focal structural defects of the ventricular wall

·       Augmentation of existing muscle

·       Correction of muscle deficiencies

·       Serve as a functional and structural replacement for dysfunctional muscle tissue

Advantages and Benefits:

The subject invention contains uniform alignment and orientation of muscle cells while providing mechanical stability and structural integrity to withstand manual manipulation, surgical procedures and the mechanical environment of the implanted tissue.


Problem Solved:

The reconstruction of dysfunctional skeletal muscle tissue has yet to be achieved. Attempts to fabricate such biomedical tissue grafts have been generally confined to experiments in which skeletal muscle cells are trapped in a collagen gel.

The current states of the art are produced in conventional tissue culture and are composed of muscle cells that lack a uniform alignment or orientation. The random nature of the cells within these sparsely populated implants limits the utility of that tissue and its ability to function as an ordinary tissue. They also lack mechanical stability or the lack the structural integrity to withstand manual manipulation, the surgical procedures and the mechanical environment of the intact tissue.

Patent Information:
Title App Type Country Serial No. Patent No. File Date Issued Date Expire Date Patent Status
Engineered Muscle Utility United States 09/386,273 6,592,623 8/31/1999 7/15/2003    
Engineered Muscle PCT United States PCT/US00/20974 -------------------- 8/2/2000      
For Information, Contact:
Technology Commercialization
University of South Carolina
Louis Terracio
David Simpson
Thomas Borg
Robert Price
Gary Bowlin
Gary Wnek
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