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Chloroacetamidine-based Inhibitors and Activity-based Probes for the Protein Arginine Methyltransferases
Reference #: 00771
Invention Description:
The present invention is a potent, irreversible inhibitor, targeting protein arginine methyltransferase 1. Inhibition studies have demonstrated that the inhibitor is a potent and selective inactivator of the enzyme. This inhibitor covalently modifies an active site residue on the enzyme.
Potential Applications:
This...
Published: 9/1/2022
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Updated: 7/5/2012
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Inventor(s): Paul Thompson, Tanesha Osborne, Obiamaka Obianyo, Corey Causey
Keywords(s):
Category(s): Chemistry and Biochemistry
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