Search Results - paul+thompson

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A Novel Screen of PAD4 Inhibitors
Reference #: 00689 Invention Description: The subject invention is an Activity-Based Protein Profiling (ABPP) assay in which a potential inhibitor compound competes with rhodamine-conjugated fluoroamidine to bind to PAD4. Fluorescence is measured to determine an estimate of the amount of fluorescent protein arginine deiminase 4 that is present in the...
Published: 9/6/2018   |   Inventor(s): Paul Thompson
Category(s): Chemistry and Biochemistry
Chloroacetamidine-based Inhibitors and Activity-based Probes for the Protein Arginine Methyltransferases
Reference #: 00771 Invention Description: The present invention is a potent, irreversible inhibitor, targeting protein arginine methyltransferase 1. Inhibition studies have demonstrated that the inhibitor is a potent and selective inactivator of the enzyme. This inhibitor covalently modifies an active site residue on the enzyme. Potential Applications: This...
Published: 9/1/2022   |   Inventor(s): Paul Thompson, Tanesha Osborne, Obiamaka Obianyo, Corey Causey
Category(s): Chemistry and Biochemistry
Protein Arginine Deiminase Inhibitors as a Novel Therapeutic Strategy for Rheumatoid Arthritis, Cancer and Other Human Diseases
Reference #: 00812Potential Applications:These Protein Arginine Deiminase Inhibitors aid in the treatment of cancer and arthritis.Advantages and Benefits:· The most potent inhibitors of PAD4 activity known to date· Have in vivo applicability· Exhibit cytotoxicity towards cells of cancerous lineage without affecting...
Published: 4/19/2018   |   Inventor(s): Paul Thompson, Corey Causey
Category(s): Biomedical and Life Sciences
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